LDL CALCULATOR (MARTIN HOPKINS )

Martin-Hopkins LDL-C Calculator

Input Lipid Profile

Parameter	Value (mg/dL)	Reference Range
Total Cholesterol		Desirable: <200 Borderline: 200-239 High: ≥240
HDL Cholesterol		Low: <40 (men), <50 (women) Normal: 40-60 High: ≥60
Triglycerides		Normal: <150 Borderline: 150-199 High: 200-499 Very High: ≥500

Results

Parameter	Value (mg/dL)	Reference Range
Non-HDL Cholesterol		Desirable: <130 Borderline: 130-159 High: 160-189 Very High: ≥190
Adjustable Factor		N/A (Calculated)
LDL Cholesterol (Estimated)		Optimal: <100 Near Optimal: 100-129 Borderline: 130-159 High: 160-189 Very High: ≥190

About the Martin-Hopkins Calculator

The Martin-Hopkins equation improves upon the Friedewald method by using a personalized adjustable factor to estimate LDL cholesterol (LDL-C). It accounts for variations in the triglyceride-to-VLDL cholesterol ratio, making it more accurate, especially in cases of low LDL-C (<70 mg/dL) or elevated triglycerides (150-400 mg/dL). The adjustable factor is derived from a 180-cell table based on triglyceride and non-HDL cholesterol levels. Formula: LDL-C = Total Cholesterol - HDL-C - (Triglycerides / Adjustable Factor) Limitations: Less reliable when triglycerides exceed 400 mg/dL; direct measurement (e.g., ultracentrifugation) remains the gold standard.

References

Martin SS, Blaha MJ, Elshazly MB, et al. Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile. JAMA. 2013;310(19):2061-2068. doi:10.1001/jama.2013.280532 Lipid reference ranges adapted from the American Heart Association and National Cholesterol Education Program (NCEP) guidelines.